During 1986, a series of special VLF transmissions at ∼3 kHz and ∼5 kHz were made from the crossed dipole antenna at Siple Station, Antarctica, which simulated transmissions from a single horizontal dipole at a number of different orientations. The subionospheric signals thus excited were recorded at four Antarctic stations: Faraday, Halley, South Pole and Arrival Heights (McMurdo Sound). The signals excited broadside to the dipole were seen to exhibit characteristics notably different from those of signals excited along the axis of the antenna, showing a minimum in received power (the depth of the minimum decreasing for the more highly attenuating paths) and increases in apparent arrival azimuth error and elevation angle. A simple computer model for mode propagation close to 5 kHz in the Antarctic Earth-ionosphere waveguide showed that these variations were the consequence of two effects: the preferential excitation of quasi-transverse magnetic (QTM) modes along the axis of the antenna and the lower attenuation of quasi-transverse electric (QTE) modes (with respect to QTM modes) over the Antarctic ice sheet. These results have important implications for studies involving the subionospheric propagation of signals with frequencies at the lower end of the VLF band and over highly attenuating surfaces, showing that QTE modes play a significant and sometimes dominant role. The propagation characteristics derived from the model may be applied to studies of the effect of burst energetic electron precipitation on subionospheric VLF signals (the Trimpi effect). Furthermore, the mode structure of subionospheric VLF signals radiated from the Siple transmitter, or a similar facility in Antarctica, may be controlled through the appropriate choice of signal frequency and antenna arrangement.
Britain hires industrial team to work on laser weapons The UK Ministry of Defence (MoD) is preparing a £30M contract which will see a number of companies join together to develop a Laser Directed Energy Weapons (DEW) capability demonstrator that will give the government an insight into laser weapon possibilities.Led by the missile producer MBDA, the industry team is named UK Dragonfire and is joined by QinetiQ, Leonardo-Finmeccanica, GKN, Arke, BAE Systems and Marshall ADG among others.UK Dragonfire’s goal will be to use what technologies are at hand to make a high energy defensive laser weapon system that will include the engagement of representative targets in land and maritime environments in 2019.The programme will also provide the body of evidence for future procurement decisions.Peter Cooper from UK’s Defence Science and Technology Laboratory said: “This is a significant demonstration programme aimed at maturing our understanding of what is still an immature technology.” It draws on innovative research into high power lasers so as to understand the potential of the technology to provide a more effective response to the emerging threats that could be faced by UK armed forces.”Rear Admiral Paul Bennett said: “The Royal Navy remains committed to the rapid exploitation of revolutionary concepts and scientific advances. The LDEW project sits alongside other cutting edge initiatives that together keep the Royal Navy at the forefront of change and well placed to be an early adopter of innovative technologies.” Authorities View post tag: Royal Navy September 19, 2016 View post tag: LDEW View post tag: MBDA Back to overview,Home naval-today Britain hires industrial team to work on laser weapons View post tag: laser weapons Share this article
Earl of Sandwich lives up to his nameThe 11th Earl of Sandwich has opened a hot sandwich shop bearing his name in London’s Ludgate Hill, with his son, Orlando Montagu. They already run 14 sandwich shops in the US, including one in Las Vegas and one at Florida’s Disneyworld, but this is their first UK store.Enter now for BIADon’t forget to get your entries in for the Baking Industry Awards 2011. This year’s carnival-themed event, on Wednesday 7 September at the Park Lane Hilton, London, includes categories such as Celebration Cake Maker of the Year and The Craft Business Award. The closing date for entries is 20 May. For details or to download an entry form visit www.bakeryawards.co.uk.MEPs agree on labelsKey nutritional information, such as fat, saturated fat, sugar, salt carbohydrates and energy content should be included on the back of packaging, MEPs agreed this week. They also included the addition of artificial trans-fats.Fire at SunstartSunstart Bakery in Ballymena, Northern Ireland, suffered a fire at its factory earlier this month, creating extensive damage. An investigation is being carried out to ascertain the cause of the fire. The firm supplies a number of UK supermarkets with own-label free-from products.
SALEM TOWNSHIP – MSAD 58’s proposed $10.35 million budget was approved by the voters of the district’s four towns Tuesday, by a combined vote of 587 in faovr to 314 opposed.Question 1 validated the proposed $10.3 million K-12 budget while Question 2 raised $20,709 for adult education.AvonQuestion 1 – 55 yes, 26 noQuestion 2 – 59 yes, 19 noKingfieldQuestion 1 – 263 yes, 52 noQuestion 2 – 263 yes, 52 noPhillipsQuestion 1 – 107 yes, 101 noQuestion 2 – 131 yes, 76 noStrongQuestion 1 – 162 yes, 135 noQuestion 2 – 185 yes, 110 noTotalQuestion 1 – 587 yes, 314 noQuestion 2 – 638 yes, 257 noThe budget represents a 6 percent increase, primarily due to salaries, benefits and contracted services which make up more than 80 percent of the budget. Local tax payers would be looking at a contribution of $4.26 million, which is a decrease of $37,000, or 0.85 percent, from the previous year, due to an increase in state subsidy and the balance forward amount.The budget includes an increase in hours for the Food Service Director and a new maintenance position.
Gov’t Mule played a rocking show last night at Houston, TX’s White Oak Music Hall, wrapping up a series of three Texas shows this week.The two-set show featured a first frame comprised entirely of original material, with Warren Haynes sprinkling in teases of John Scofield’s “Hottentot”, a tune off A Go Go, his 1997 collaborative release with Medeski, Martin & Wood. Gov’t Mule’s second set and encore saw the band weave in a number of covers, including a “St. Stephen Jam”, and a cover of The Beatles’ “She Said, She Said”.The highlight of the show’s second half came when the band moved through “Bed Of Lies”, played for the first time live. “Bed Of Lies” is one of two previously unreleased tracks from the Revolution Come… Revolution Go sessions, a special release Gov’t Mule put together for Record Store Day this past spring.You can watch a crowd-shot video of “Soulshine”, from Gov’t Mule’s performance at White Oak Music Hall below:Gov’t Mule – “Soulshine” – 9/21/2018[Video: William Castleman]For a full list of Gov’t Mule’s upcoming performances and ticketing information, head to the band’s website here.Setlist: Gov’t Mule | White Oak Music Hall | Houston, TX | 9/21/2018Set One: Slackjaw Jezebel, Thorazine Shuffle, Million Miles From Yesterday, Child Of The Earth, Birth Of The Mule, Funny Little Tragedy with Message In A Bottle lyrics, Pressure Under Fire, Time To ConfessSet Two: Inside Outside Woman Blues, Burning Point, Sarah Surrender, Trane > Eternity’s Breath > St. Stephen Jam, Bed Of Lies, She Said, She Said > Tomorrow Never Knows, SoulshineEncore: Come On Into My Kitchen > Gonna Send You Back To Georgia[H/T Jambase]
New research led by Harvard scientist Amy Wagers has demonstrated that gene-editing machinery can be delivered straight to stem cells where they live, rather than in a dish. Published in Cell Reports, the findings have major implications for biotechnology research and the development of therapeutics for genetic diseases.“If you want to change a genome to correct a disease-causing gene mutation, you have to change it in the relevant stem cells,” said Wagers, the Forst Family Professor of Stem Cell and Regenerative Biology. “If you don’t change the stem cells, whatever cells you do fix may eventually be replaced with diseased cells fairly quickly. If you do fix the stem cells, they will create healthy cells that can eventually replace the diseased cells.”But fixing stem cells is harder than it sounds. The way it works now, stem cells have to be extracted, kept alive and healthy, genetically altered, then put back in the patient’s body. The process is disruptive for the cells, which may ultimately be rejected or fail to engraft back into the patient.Each type of stem cell lives in its own “niche,” well-protected in hard-to-reach areas such as bone marrow. “When you take stem cells out of the body, you take them out of the very complex environment that nourishes and sustains them, and they kind of go into shock,” Wagers said. “Isolating cells changes them. Transplanting cells changes them. Making genetic changes without having to do that would preserve the regulatory interactions of the cells — that’s what we wanted to do.”Transport by virusWagers’ group used an adeno-associated virus (AAV) that infects human (and mouse) cells—but does not cause disease—as a transport vehicle. Building on their earlier work in mice with Duchenne muscular dystrophy, Wagers and her colleagues created various AAV packages to deliver gene-editing cargo into several different types of skin, blood, and muscle stem and progenitor cells.“This was a true collaboration between labs specializing in several different organs,” said Jill Goldstein, a postdoctoral fellow in the Wagers lab and co-first author of the study. “We set up experiments in our organs of interest, analyzed them, compared notes, and made adjustments in a kind of scientific assembly line. None of us could have done it alone — it takes a lot of hands, and the team approach made it really fun.”To test whether their AAV complexes managed to deliver, the researchers used mice that act as so-called reporter systems via a “reporter” gene that is normally silenced but can be turned on by gene editing. When the reporter gene is activated, the cell turns bright, fluorescent red.Up to 60 percent effectiveThe researchers observed that in skeletal muscle, up to 60 percent of the stem cells turned fluorescent red. In cells that give rise to different types of skin cells, up to 27 percent of the cells turned red. Up to 38 percent of the stem cells in bone marrow (which make blood) were changed. That might seem low, but blood turns over so quickly that in some cases even a single healthy stem cell may be sufficient to rescue a defect.“So far, the concept of delivering healthy genes to stem cells using AAV hasn’t been practical because these cells divide so quickly in living systems — so the delivered genes will be diluted from the cells rapidly,” said Sharif Tabebordbar, an alumnus of Harvard’s Department of Stem Cell and Regenerative biology and now a postdoctoral fellow at the Broad Institute. “Our study demonstrates that we can permanently modify the genome of stem cells, and therefore their progenies, in their normal anatomical niche. There is a lot of potential to take this approach forward and develop more durable therapies for different forms of genetic diseases. That includes different forms of muscular dystrophy, where tissue regeneration is such an important factor.”“We looked at the skin of these AAV-transduced mice from the Wagers lab, and were pleased to see that many dermal cells were successfully edited as well,” said Ya-Chieh Hsu, Alvin and Esta Star Associate Professor of Stem Cell and Regenerative Biology. “Those included cells that give rise to dermal adipocytes, and cells that help regulate other stem cells in the skin. We’ve always needed a tool that lets us manipulate dermal cells in vivo rapidly — so for us, this is like a dream come true.”‘Things might start to move very quickly’Delivering a gene therapy directly into a living system has been a barrier for biotech companies trying to develop therapies for diseases like spinal muscular atrophy.“This is a really important resource for the community for two reasons,” Wagers said. “First, it changes the way we can study stem cells in the body. The AAV approach lets researchers investigate the importance of different genes for stem cells in their native environment, much more quickly than ever before. Because the delivery system is so robust, it can also be used to target genes that affect many different tissues. Related Harvard scientists receive grant funding through NIH program “Secondly, it’s an important step toward developing effective gene therapies. The approach we developed gets around all the problems you introduce by taking stem cells out of a body and allows you to correct a genome permanently. AAVs are already being used in the clinic for gene therapy, so things might start to move very quickly in this area.”This study was supported in part by awards and grants from Harvard University (Star Family Challenge Award, Dean’s Initiative Fund, and Harvard Stem Cell Institute Blood Program Pilot Award), the New York Stem Cell Foundation, the National Institutes of Health, a Harvard Stem Cell Institute Junior Faculty Award, the Pew Charitable Trusts, a Smith Family Foundation Odyssey Award, and the American Cancer Society, among others. Source article: Goldstein J.M., Tabebordbar M., et al. (2019) In situ modification of tissue stem and progenitor cell genomes. Cell Reports (in press). No clock, no crystal ball, but lots of excitement — and ambition — among Harvard scientists Seven recognized for high-risk, high-reward research How old can we get? It might be written in stem cells
Recent actions by the Congress of the United States in proposing legislation aimed at providing regulatory relief for credit unions sends a clear and distinct message to the NCUA Board. Address the issues that that you should or we will do it for you.By putting off discussing and acting on issues like supplemental capital, revised exam scheduling, transparent budget hearings and significant member business lending revisions, the NCUA Board is risking losing their authority as a regulator and insurer to be the decision making body on credit union matters. Failing to address controversial subjects where positions need to be taken and hard decisions made has resulted in the trade associations pursuing their agendas directly with Congress. Not to say that certain issues do not require legislative action, but we have reached a point where Congress is being asked to address and rectify issues that are in the discretion of the NCUA Board.Credit unions need to understand that the last thing they want is to deal with the 535 members of Congress on day to day issues that impact their operations. Opening the door to the belief that they have to go to Capitol Hill every time credit unions feel the NCUA Board is dragging their feet is creating a path that neither credit unions or the Board should want to go down.The NCUA Board by statute is the place to address the issues they are empowered to deal with. That is where credit unions and their trade associations must make the effort to accomplish regulatory changes the Board can readily handle. Dealing with three people, and now two, should be a lot easier than trying to convince 535 individuals.The federal government moves very slow and accomplishes a lot less that they should. In some areas, NCUA is right in line with that dreaded philosophy. There is no reason why credit unions should have to wait months or even years for the Board to openly discuss areas of concern and one way or the other make a decision on a course of action. A prime example is the question of whether or not to allow a cycle of 18 months for examination of well-run credit unions. It is an issue that should be addressed now and resolved now not later.When someone fails to do their job someone else usually step up and in to fill the void and do what needs to be done. The NCUA Board cannot allow that pattern to continue and impact their operations.I don’t know anyone who really wants the Congress to take over the decision making for credit union regulation. That is a slippery slope to go down. Let’s hope the NCUA Board can avoid that direction. 4SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,Michael Fryzel Michael Fryzel is the former Chairman of the National Credit Union Administration and is now a financial services consultant and government affairs attorney in Chicago. He can be reached at … Details
The highest rate of positive PCR tests by type of work was 31% for people in the bar and restaurant industry, which includes such nightlife businesses as host and hostess clubs, The Yomiuri Shimbun has learned.The data came from PCR tests for the novel coronavirus administered in June by Shinjuku Ward in Tokyo.The Shinjuku Ward Office commissioned medical institutions to conduct tests on people in the ward and the 31% rate was about eight times higher than the 4% for company employees, showing the high risk of infection in the nightlife industry. “It is possible that hosts were infected through shared living arrangements,” Shinjuku Ward Mayor Kenichi Yoshizumi said.The ward government will conduct research on the routes of the infections. In addition to public health centers, PCR tests are available at a location within the National Center for Global Health and Medicine set up by the center and the ward’s medical society. According to the ward, of the 1,266 people who underwent tests at this location in June, 226, or 18%, tested positive.The restaurant industry had 133 out of 429 people (31%) test positive. Most of them worked in hospitality such as host and hostess clubs. This was followed by the category that included the unemployed and part-time workers at 24%, while those of students and of company employees marked 4% each. For those whose job status was unknown, the rate was 16%.Infections were reported at about 30 out of about 240 host clubs scattered throughout the Kabukicho nighttime entertainment district. More than 10 of them saw group infections of at least five people. Topics :
Comment Phil HaighWednesday 29 May 2019 8:23 amShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link It is going to be a tense London derby in Azerbaijan (Picture: Getty Images)What TV channel is the Europa League final on?AdvertisementAdvertisementBT Sport 2 will be showing the game live with coverage from 6.30pm (kick-off at 8pm).There are various ways of getting BT Sport, either with BT Broadband or by adding it to your Sky or TalkTalk package, which are detailed here.Is it on any free to air TV channels?No, it is only being shown on BT Sport.More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityHow can I watch Arsenal vs Chelsea for free?Thankfully, BT Sport are being quite generous and showing the final for free on the BT Sport website, their app and on their YouTube channel.The same situation will apply for the Champions League final between Liverpool and Tottenham on Saturday.MORE: Arsenal vs Chelsea Europa League final time, odds, team news and head-to-headMORE: Eden Hazard prepares for perfect Chelsea send-off in Europa League final as Arsenal rue contract missteps Advertisement Arsenal and Chelsea will battle it out in Baku (Picture: Getty Images)All eyes will be on Baku on Wednesday night as Arsenal and Chelsea battle it out for the Europa League title.Premier League sides are contesting both the Europa and Champions League finals this week and either the Gunners or the Blues will be getting their hands on the first European title of the season.Maurizio Sarri’s Chelsea side are the favourites to lift the trophy having finished third in the Premier League, compared to Arsenal’s fifth, however, they have only won one of their last eight meetings against Unai Emery’s team.It has been a turbulent build-up to the contest, with political tension ruling out Arsenal midfielder Henrikh Mkhitaryan and plenty of off-field struggles for Chelsea which could see them lose both their manager and star player after the match.ADVERTISEMENT What TV channel is the Europa League final on and how to watch Arsenal vs Chelsea for free? Advertisement
Eurotunnel’s Le Shuttle car-carrying service has been relaunched following the repair of fire damage to the Channel Tunnel (RG 1.97 p21), starting with several weeks of special events under the ’Happy Summer’ banner. Managing Director Bill Dix announced on June 10 that 60 to 65% of capacity would henceforth be reservable, requiring a public timetable for the first time. On-train refreshments are to be provided along with initiatives such as children’s activity packs and non-shopping tourist itineraries. Services will run up to four times an hour at peak times, with one per hour during the night. o