HealthLifestyle Alzheimer’s could be stopped from progressing after scientists find disease ‘spreads like an infection’ by: – February 2, 2012 17 Views no discussions Share Sharing is caring! Tweet Share Brain effect: This computer graphic shows a slice of the brain of an Alzheimer patient (left) compared with a normal brain (right). The Alzheimer’s brain is considerably shrunkenAlzheimer’s disease spreads in a predictable pattern like an infection, going from one brain cell to another along linked circuits known as synapses, researchers say.The findings, published in the online journal PloS One, suggest that blocking the process early on may keep the disease from spreading.‘This is a phenomenon that is increasingly recognised and potentially very important,’ said Dr Samuel Gandy, of the Mount Sinai Alzheimer’s Disease Research Center in New York.‘If we understood this process, we could potentially arrest progression at an early stage.’Imaging studies in people have suggested that Alzheimer’s spreads from region to region in the brain rather than popping up spontaneously in different areas, but the evidence was not strong enough to say for sure.‘Everyone talks about Alzheimer’s ‘spreading’, but there really has not been a standard theory,’ study authors Dr Karen Duff and Dr Scott Small from the Columbia University Medical Center in New York, said.‘In the past, we have asked many of our colleagues in the field of Alzheimer’s research what they mean when they say ‘spread’. Most think that the disease just pops up in different areas of the brain over time, not that the disease actively jumps from one area to the next,’ they said.‘Our findings show for the first time that the latter might be true.’More than five million Americans and 465,000 people in the UK suffer from Alzheimer’s, a brain disease that causes dementia.Despite costly efforts, no drug has been found that can keep the disease from progressing.For their study, the team used mice that were genetically engineered to accumulate deposits of tau in a key memory center of the brain known as the entorhinal cortex, which is where that toxic protein starts to deposit in people.Their aim was to map the progression of tau, an abnormal protein that forms tangles of protein fibers in the brains of people with Alzheimer’s disease.The team analysed the brains of the mice periodically over a period of 22 months to see how the disease progressed.They found that as the mice aged, the abnormal human tau spread along a linked pathway, traveling from the entorhinal cortex to the hippocampus to the neocortex, areas of the brain needed to form and store memories.That pattern closely follows the progression of Alzheimer’s as it passes through various stages in people, Dr Duff said.The team also saw signs that tau moved from brain cell to brain cell across synapses, connection points that allow nerve cells to communicate.The researchers think those findings suggest new strategies for diagnosing and treating Alzheimer’s disease.‘First, it would suggest that imaging tools that can detect entorhinal cortex dysfunction will be particularly helpful in diagnosing the earliest stages of the disease,’ they said.‘More importantly, it might suggest ways of improving treatment.‘The implication of our study is that if it were possible to ‘treat’ Alzheimer’s when it was first detected in the entorhinal cortex, this would prevent spread,’ they said.They likened the approach to treating cancer early, when it is still in one spot, and not waiting until it has spread.The study may bring a new focus to diagnostics and treatments that focus on tau, rather than amyloid, the protein that causes plaques to form in the brain.Current imaging agents used with PET scanners can identify amyloid deposits in the brain, but not tau.Most late-stage Alzheimer’s drugs, including Eli Lilly and Co’s solanezumab, and Johnson & Johnson and Pfizer’s bapineuzumab, take aim at amyloid, which accumulates silently 15 to 20 years before signs of dementia appear.By Reuters ReporterDaily Mail Share
The top-ranked USC women’s water polo team ended March on a tear, pouring on the goals to take down visiting No. 14 San Jose State 19-3 and No. 18 Hartwick 21-5 at the Uytengsu Aquatics Center on Saturday to remain perfect on the season and extend their national women’s record winning streak to 51 matches in a row.USC (24-0, 2-0 MPSF) was led by senior 2-meter Brigitta Games, who had a career scoring day in the pool. The All-American recorded a whopping 11 goals in just two games, highlighted by a career-high seven-goal outburst against San Jose State in the first match and a four-goal outing against Hartwick in the second. The Trojans also played some lockdown defense to hold both opponents scoreless in the second half of each game, as all three USC goalies saw time in the cage and allowed a combined total of just eight goals. All in all, USC outscored its opponents by a 40-8 margin.In the conference match against San Jose State, Games was nearly unstoppable from 2-meters, scoring four goals in a row early while recording a career-high five goals by halftime to give USC the 10-3 advantage. Two more strikes by Games would get past the Spartan goalie in the second half, while USC’s own netminders put the clamps down on the Spartan offense and held them scoreless the rest of the way. Junior Victória Chamorro, who made the start in goal, finished with four saves, while freshman Holly Parker came in relief in the fourth period and recorded two stops to help USC secure the 19-3 win.In addition to Games’ seven goals, senior driver Stephania Haralabidis punched in four goals while freshman driver Denise Mammolito, freshman utility Maud Megens and senior driver Ioanna Haralabidis each scored twice. Junior utility Hayley McKelvey and sophomore driver Courtney Fahey added one goal apiece as the Trojans outshot San Jose State, 33-18. With the win, USC ended the Spartans’ two-match winning streak and reached 50 games in their own win streak.Once that match was over, USC faced off against No. 18 Hartwick in a nonconference bout. The Hawks kept it close in the first period by trading early scores, but USC pushed ahead to lead 6-3 at the end of the frame. On a man-up advantage early in the second period, Stephania Haralabidis scored the Trojans’ 10th goal, one that would move her up to No. 2 all-time in career scoring at USC.One final strike with 10 seconds left before the half by junior driver Brianna Daboub allowed the Trojans to carve out a 14-5 advantage and they never looked back, scoring seven more goals and holding Hartwick scoreless to finish with the 21-5 victory. Games tallied four goals, while Stephania Haralabidis and Megens scored three each. The swarming USC defense was also too much for the Hawks to handle, as McKelvey recorded a game-high five steals and sophomore goalkeeper Amanda Longan notched 10 saves in just three periods.While the Spartans and the Hawks don’t pose quite the same threat as the likes of Stanford and UCLA do, Trojan head coach Jovan Vavic has instilled a high level of discipline and accountability that his players, like Ioanna Haralabidis, have responded well to.“We have the benefit of a coach like Jovan, who always keeps us on edge,” Haralabidis said. “He pushes us hard every single day in practice and in games and tells us that even though they might not be the best team out there this season, we still have to respect them and perform well in order to win. We like when he pushes us like that because in the end, it makes us stronger players.”USC will now get to stay in its home waters for the back end of a five-game home stand as they host No. 6 Arizona State in an MPSF conference match on Saturday. The battle with the Sun Devils will begin at 12:30 p.m. at the Uytengsu Aquatics Center and will be broadcast live on Pac-12 Network.
Patrick Beverley did not miss any games after observing a four-day quarantine period but Montrezl Harrell is yet to return as he mourns his grandmother’s death.”It’s extremely difficult, man,” Williams added. “I truly was grieving two weeks ago. I was really going through something. I was thrown under the bus, you know what I’m saying?”All the attention turned to Magic City because it’s a gentlemen’s club. I feel like if I was at a steakhouse or Hooters or whatever, it wouldn’t be half the story.” Under NBA rules, Williams was then due to observe a four-day quarantine period upon his return to Florida, yet that was extended to 10 days — a period encompassing the Clippers’ first two games — after it emerged he also took a trip to the gentlemen’s club, Magic City, in Atlanta.The 33-year-old is a frequent visitor to Magic City — a place also renowned for its chicken wings — describing it as his “favorite restaurant” in Atlanta, though he admitted his latest visit was an ill-judged one.MORE: Everything to know about the NBA bubble”In hindsight, I think as far as the public safety issue goes, I probably could have made a better-quality decision,” he told reporters after the Clippers’ 117-115 loss to the Phoenix Suns. “I was a little naive in that aspect. I went somewhere after a viewing of somebody I considered a mentor, somebody I looked up to, first black man I seen with legal money in my life.Ask any of my teammates what’s my favorite restaurant in Atlanta is. Ain’t nobody partying. Chill out lol #Maskon #inandout— Lou Williams (@TeamLou23) July 24, 2020″It’s been documented how much I talk about [Magic City], how much I eat there. I just did something that was routine for me. I frequent that place at that time of day, 5:30, 6 in the afternoon.”At the time, I thought I was making a responsible decision. After looking back on it, with everything going on in the world, the pandemic, maybe it wasn’t the best-quality decision. I chalk it up as that, take my L and keep moving.”Williams, who had seven points, six assists and six rebounds against the Suns, was one of three Clippers players granted a leave of absence by the NBA for personal reasons. Clippers guard Lou Williams conceded he could have made “a better-quality decision” after being forced to miss NBA games because he visited a strip club in Atlanta.Williams, the reigning Sixth Man of the Year, had been allowed to leave the NBA’s ‘bubble’ in Orlando last month to return to Georgia to attend the wake of a friend’s father.