爱上海,上海419论坛,上海龙凤419 - Powered by 住涉外怎么玩到妹子

Alzheimer’s could be stopped from progressing after scientists find disease ‘spreads like an infection’

first_imgHealthLifestyle Alzheimer’s could be stopped from progressing after scientists find disease ‘spreads like an infection’ by: – February 2, 2012 17 Views   no discussions Share Sharing is caring! Tweetcenter_img Share Brain effect: This computer graphic shows a slice of the brain of an Alzheimer patient (left) compared with a normal brain (right). The Alzheimer’s brain is considerably shrunkenAlzheimer’s disease spreads in a predictable pattern like an infection, going from one brain cell to another along linked circuits known as synapses, researchers say.The findings, published in the online journal PloS One, suggest that blocking the process early on may keep the disease from spreading.‘This is a phenomenon that is increasingly recognised and potentially very important,’ said Dr Samuel Gandy, of the Mount Sinai Alzheimer’s Disease Research Center in New York.‘If we understood this process, we could potentially arrest progression at an early stage.’Imaging studies in people have suggested that Alzheimer’s spreads from region to region in the brain rather than popping up spontaneously in different areas, but the evidence was not strong enough to say for sure.‘Everyone talks about Alzheimer’s ‘spreading’, but there really has not been a standard theory,’ study authors Dr Karen Duff and Dr Scott Small from the Columbia University Medical Center in New York, said.‘In the past, we have asked many of our colleagues in the field of Alzheimer’s research what they mean when they say ‘spread’. Most think that the disease just pops up in different areas of the brain over time, not that the disease actively jumps from one area to the next,’ they said.‘Our findings show for the first time that the latter might be true.’More than five million Americans and 465,000 people in the UK suffer from Alzheimer’s, a brain disease that causes dementia.Despite costly efforts, no drug has been found that can keep the disease from progressing.For their study, the team used mice that were genetically engineered to accumulate deposits of tau in a key memory center of the brain known as the entorhinal cortex, which is where that toxic protein starts to deposit in people.Their aim was to map the progression of tau, an abnormal protein that forms tangles of protein fibers in the brains of people with Alzheimer’s disease.The team analysed the brains of the mice periodically over a period of 22 months to see how the disease progressed.They found that as the mice aged, the abnormal human tau spread along a linked pathway, traveling from the entorhinal cortex to the hippocampus to the neocortex, areas of the brain needed to form and store memories.That pattern closely follows the progression of Alzheimer’s as it passes through various stages in people, Dr Duff said.The team also saw signs that tau moved from brain cell to brain cell across synapses, connection points that allow nerve cells to communicate.The researchers think those findings suggest new strategies for diagnosing and treating Alzheimer’s disease.‘First, it would suggest that imaging tools that can detect entorhinal cortex dysfunction will be particularly helpful in diagnosing the earliest stages of the disease,’ they said.‘More importantly, it might suggest ways of improving treatment.‘The implication of our study is that if it were possible to ‘treat’ Alzheimer’s when it was first detected in the entorhinal cortex, this would prevent spread,’ they said.They likened the approach to treating cancer early, when it is still in one spot, and not waiting until it has spread.The study may bring a new focus to diagnostics and treatments that focus on tau, rather than amyloid, the protein that causes plaques to form in the brain.Current imaging agents used with PET scanners can identify amyloid deposits in the brain, but not tau.Most late-stage Alzheimer’s drugs, including Eli Lilly and Co’s solanezumab, and Johnson & Johnson and Pfizer’s bapineuzumab, take aim at amyloid, which accumulates silently 15 to 20 years before signs of dementia appear.By Reuters ReporterDaily Mail Sharelast_img read more

Read More

Angels end Brad Ausmus’ first season with 90th loss, most since 1999

first_img Newsroom GuidelinesNews TipsContact UsReport an Error Angels’ Mike Trout working on his defense, thanks to Twitter Angels’ poor pitching spoils an Albert Pujols milestone Angels offense breaks out to split doubleheader with Astros PreviousHouston Astros’ Aledmys Diaz, right, applauds as he touches home plate after hitting a solo home run with Los Angeles Angels catcher Anthony Bemboom looking down during the second inning of a baseball game in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo)Houston Astros’ Jose Altuve, right, slides into third, beating the throw to Los Angeles Angels third baseman Matt Thaiss, during the first inning of a baseball game in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo) SoundThe gallery will resume insecondsLos Angeles Angels starting pitcher Dillon Peters throws to a Houston Astros batter during the first inning of a baseball game in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo)Houston Astros’ George Springer, center, gets congratulations from teammates after hitting a solo home run against the Los Angeles Angels during the second inning of a baseball game in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo)Houston Astros’ Jose Altuve, left, congratulates George Springer, right, for hitting a solo home run against the Los Angeles Angels during the second inning of a baseball game in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo)Houston Astros’ Aledmys Diaz, right, smiles as he is gets congratulations from Robinson Chirinos, left, and other teammates after hitting a solo home run against the Los Angeles Angels during the second inning of a baseball game in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo)Houston Astros center fielder Jake Marisnick, right, congratulates and hugs George Springer for scoring on an RBI-double by Jose Altuve during the first inning of a baseball game against the Los Angeles Angels in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo)Houston Astros starting pitcher Gerrit Cole throws to a Los Angeles Angels batter during the first inning of a baseball game in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo)Houston Astros starting pitcher Gerrit Cole throws to a Los Angeles Angels batter during the first inning of a baseball game in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo)Los Angeles Angels manager Brad Ausmus looks out at the field during the first inning of a baseball game against the Houston Astros in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo)Houston Astros’ Aledmys Diaz, right, applauds as he touches home plate after hitting a solo home run with Los Angeles Angels catcher Anthony Bemboom looking down during the second inning of a baseball game in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo)NextShow Caption1 of 10Houston Astros’ Aledmys Diaz, right, applauds as he touches home plate after hitting a solo home run with Los Angeles Angels catcher Anthony Bemboom looking down during the second inning of a baseball game in Anaheim, Calif., Sunday, Sept. 29, 2019. (AP Photo/Alex Gallardo)ExpandANAHEIM — After the Angels’ 8-5 loss to the Houston Astros on Sunday, their nightmarish season came to an end with 90 losses.It was the first time they’d reached that level of futility since 1999, the year before Mike Scioscia was hired as manager.In the first year after Scioscia left, the Angels finished 72-90 under Brad Ausmus. He was at the helm throughout a season that included the tragic loss of Tyler Skaggs and numerous injuries to key players.As the season came to a close, there was a report that the Angels would  consider replacing Ausmus with Joe Maddon if he parted ways with the Chicago Cubs. About an hour after Maddon’s departure from the Cubs became official on Sunday morning, Ausmus shrugged off the rumors. “I have a contract,” said Ausmus, who is signed through 2021. “That’s the only thing I know.”Ausmus added that he’d been through a similar experience in 2015, following his second year managing the Detroit Tigers.“It came out I was being fired,” he said. “I was there for two more years. So you learn to take it with a grain of salt. Most of the decisions are not under my control, so I don’t worry too much about it.”General manager Billy Eppler is scheduled to meet with the media on Monday to discuss the season and the plans for the future.Ausmus added that he and Eppler “get along great, actually. Our relationship is very strong.”center_img Angels’ Shohei Ohtani spending downtime working in outfield The results, of course, were not good. While the bulk of the team’s problems were related to injuries and poor performance of the players, Ausmus said he was satisfied with the parts of his job that he could control.“Actually, if you talk about from a tactical or strategy standpoint, I thought it went well,” Ausmus said. “My time in Detroit served well in terms of experience. Responding to situations that happened on the field, I thought the clubhouse was extremely smooth. I think the guys got along well. They laughed together, they played hard together, they worked together. It was a good group of guys. So I thought those things overall went well.”Related Articles The biggest single reason for the Angels failures was a lack of starting pitcher, so it was coincidental that their final loss came at the hands of the pitcher that many hope can be a part of the solution in 2020.Gerrit Cole, a product of Orange Lutheran High and UCLA, struck out 11 in five innings to complete his campaign for the Cy Young award.This winter Cole is expected to be the top available player on the free agent market. The Angels will no doubt pursue Cole, who still lives in Orange County, and they will likely be on his short list of finalists.The only run the Angels managed against Cole came on a homer by Matt Thaiss, who later added a two-run shot against reliever Brad Peacock. It was the second multi-homer game of the season for Thaiss.Thaiss added an RBI double in the eighth, pulling the Angels within 8-5 after they had trailed 8-1.That was as close as the Angels could get, and soon after their disappointing season came to an official end.“There were some positives, but most of the positives were on individual levels,” Ausmus said. “I think, quite frankly, I’m ready at this point to put it behind me. It was a tough year.” Jose Suarez’s rocky start sinks Angels in loss to Astros last_img read more

Read More